Docs improvememnts, more flexible Keras dependency, drop typechecks dependency, remove some unused functions

* Switch from JSON to YAML for hyperparameters
* Pin tensorflow (hoping will help with #110)

Fixes #47.

Pin keras version. Also add note on KERAS_BACKEND to README.md.

Closes #67. Closes #65.

Fixes #54

Fixes #59

Lazily putting this all in one commit.

* infrastructure for downloading datasets and published trained models (the `mhcflurry-downloads` command)
* docs and scripts (in `downloads-generation`) to generate the pubilshed datsets and trained models
* parallelized cross validation and model training implementation, including support for imputation (based on the old mhcflurry-cloud repo, which is now gone)
* a single front-end script for class1 allele-specific cross validation and model training / testing (`mhcflurry-class1-allele-specific-cv-and-train`)
* refactor how we deal with hyper-parameters and how we instantiate Class1BindingPredictors
* make Class1BindingPredictor pickleable and remove old serialization code
* move code particular to class 1 allele-specific predictors into its own submodule
* remove unused code including arg parsing, plotting, and ensembles
* had to bump the binding prediction threshold for the Titin1 epitope from 500 to 700, as this test was sporadically failing for me (see test_known_class1_epitopes.py)
* Attempt to make tests involving randomness somewhat more reproducible by setting numpy random seed
* update README